I wrote this script for this video a pitch we had for this amazing new antibody-drug conjugate that was scheduled to launch this year.
Andrew Ricard did a beautiful job editing. I think it’s a pretty universal picture of the dynamic therapeutic landscape in oncology for the next few years. I really wish we would have won this pitch. This drug was about as cool as it gets.
The treatment is a combination of 3 distinct components that are physically bonded together and infused into the bloodstream. One component is an antibody that has a very strong affinity for a receptor (Nectin-4) that is highly expressed on the surface of cancer cells. So it acts almost like an airplane that delivers the other 2 components directly to cancer cells—leaving healthy cells that don’t express Nectin-4 alone.
Once attached to that receptor, the antibody along with its cytotoxic payload (a very powerful chemotherapy drug) are pulled into the cancer cell as a form of endocytosis. Once inside, the linker holding everything together is cleaved which activates the chemotherapy and causes the cancer cell to self-destruct.
Like I said, this is about as cool as it gets. Not only does this selective targeting reach previously unreachable, inoperable and highly resistant cancers with a highly effective way to kill cancer, the specificity of this newly identified target reduces the side effects caused by traditional treatments that are equally lethal to healthy cells.
The disease awareness campaign here was built around introducing the target receptor in a provocative, memorable way. We called this creative platform “The Achilles Protein” and developed metaphorical ideas for depicting why it’s so important relative to highly resistant cancer types.
This is all “pitch” work so the ideas were never produced and my description of the conceptual nature should not be interpreted as product promotion in any way.
*I apologize for the quality of the video samples. YouTube downsamples everything with their free service and I’m currently looking for a better video hosting service.